Induction of endoreduplication in cultured mammalian cells by some chemical mutagens.
نویسندگان
چکیده
Chinese hamster cells treated with such chemical mutagens as 4-nitroquinoline 1-oxide, captan, acridine dyes, and Cytoxan developed diplochromosomes, showing the induction of endoreduplication. This indicates that these mutagens not only cause damage to genes but also cause changes in ploidy. In this study, the maximum ratio of endoreduplicated cells, 6.6%, was obtained when cells were treated with Cytoxan, 5 mg/ml for 6 hr. Ethyl methanesulfonate, triethylenephosphoramide, and Af-methyl-A/'-nitro-jV-nitrosoguanidine, all
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عنوان ژورنال:
- Cancer research
دوره 34 10 شماره
صفحات -
تاریخ انتشار 1974